Molecular Similarity of MDR Inhibitors

Zloh, Mire and Gibbons, Simon (2004) Molecular Similarity of MDR Inhibitors. International Journal of Molecular Sciences, 5 (2). pp. 37-47. ISSN 1661-6596

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The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 01 Jul 2020 00:01
Last Modified: 01 Jul 2020 00:01
DOI: 10.3390/i5020037

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