Molecular similarity of MDR inhibitors

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Zloh, Mire and Gibbons, Simon (2004) Molecular similarity of MDR inhibitors. International Journal of Molecular Sciences, 5 (2). pp. 37-47. ISSN 1661-6596

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Abstract

The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.mdpi.com/1422-0067/5/2/37
Depositing User:	LivePure Connector
Date Deposited:	01 Jul 2020 00:01
Last Modified:	04 Mar 2024 17:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75854
DOI:	10.3390/i5020037

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