Bioactive constituents of Artemisia monosperma

Stavri, Michael, Ford, Christopher H. J., Bucar, Franz, Streit, Bernhard, Hall, Michael L., Williamson, R. Thomas, Mathew, K. T. and Gibbons, Simon (2005) Bioactive constituents of Artemisia monosperma. Phytochemistry, 66 (2). pp. 233-239. ISSN 0031-9422

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Abstract

During a study on the chemistry and biological activity of Kuwaiti plants, new metabolites including 4,6-dihydroxy-3-[3′-methyl-2′-butenyl]-5-[4″-hydroxy-3″-methyl-2″-butenyl]-cinnamic acid (1), the 3R,8R stereoisomer of the C17 polyacetylene dehydrofalcarindiol (2) and a C10 polyacetylene glucoside (3) were characterised by spectroscopic means. Additionally, the previously characterised natural products 1,3R,8R-trihydroxydec-9-en-4,6-yne (4), spathulenol (5) and eriodyctiol-7-methyl ether (6) were also isolated. Compounds 2, 3, and 4 were evaluated for their ability to inhibit the enzyme 12-lipoxygenase and 3 and 4 showed moderate activity at 30 μg/ml. Compound 2 was evaluated against a panel of colorectal and breast cancer cell lines and IC50 values ranged from 5.8 to 37.6 μg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64–128 μg/ml.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 30 Jun 2020 00:20
Last Modified: 30 Jun 2020 00:20
URI: https://ueaeprints.uea.ac.uk/id/eprint/75831
DOI: 10.1016/j.phytochem.2004.11.010

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