Stavri, Michael, Ford, Christopher H. J., Bucar, Franz, Streit, Bernhard, Hall, Michael L., Williamson, R. Thomas, Mathew, K. T. and Gibbons, Simon (2005) Bioactive constituents of Artemisia monosperma. Phytochemistry, 66 (2). pp. 233-239. ISSN 0031-9422
Full text not available from this repository.Abstract
During a study on the chemistry and biological activity of Kuwaiti plants, new metabolites including 4,6-dihydroxy-3-[3′-methyl-2′-butenyl]-5-[4″-hydroxy-3″-methyl-2″-butenyl]-cinnamic acid (1), the 3R,8R stereoisomer of the C17 polyacetylene dehydrofalcarindiol (2) and a C10 polyacetylene glucoside (3) were characterised by spectroscopic means. Additionally, the previously characterised natural products 1,3R,8R-trihydroxydec-9-en-4,6-yne (4), spathulenol (5) and eriodyctiol-7-methyl ether (6) were also isolated. Compounds 2, 3, and 4 were evaluated for their ability to inhibit the enzyme 12-lipoxygenase and 3 and 4 showed moderate activity at 30 μg/ml. Compound 2 was evaluated against a panel of colorectal and breast cancer cell lines and IC50 values ranged from 5.8 to 37.6 μg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64–128 μg/ml.
Item Type: | Article |
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Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Science > School of Pharmacy |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 30 Jun 2020 00:20 |
Last Modified: | 22 Oct 2022 06:23 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/75831 |
DOI: | 10.1016/j.phytochem.2004.11.010 |
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