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ToolsHorton, Rebecca, Wileman, Thomas and Rushworth, Stuart A (2020) Autophagy driven extracellular vesicles in the leukaemic microenvironment. Current Cancer Drug Targets, 20 (7). 501 - 512. ISSN 1568-0096
Full text not available from this repository. (Request a copy)Abstract
The leukaemias are a heterogeneous group of blood cancers, which together, caused 310,000 deaths in 2016. Despite significant research into their biology and therapeutics, leukaemia is predicted to account for an increased 470,000 deaths in 2040. Many subtypes remain without targeted therapy, and therefore the mainstay of treatment remains generic cytotoxic drugs with bone marrow transplant the sole definitive option. In this review, we will focus on cellular mechanisms which have the potential for therapeutic exploitation to specifically target and treat this devastating disease. We will bring together the disciplines of autophagy and extracellular vesicles, exploring how the dysregulation of these mechanisms can lead to changes in the leukaemic microenvironment and the subsequent propagation of disease. The dual effect of these mechanisms in the disease microenvironment is not limited to leukaemia; therefore, we briefly explore their role in autoimmunity, inflammation and degenerative disease.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
| Uncontrolled Keywords: | autoimmunity,autophagy,extracellular vesicles,leukaemia,therapeutic,tumour microenvironment,oncology,pharmacology,drug discovery,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Jun 2020 00:01 |
| Last Modified: | 19 Oct 2023 02:41 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/75769 |
| DOI: | 10.2174/1568009620666200428111051 |
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