Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

Stavri, Michael, Mathew, K.t., Gordon, Andrew, Shnyder, Steven D., Falconer, Robert A. and Gibbons, Simon (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. Phytochemistry, 69 (9). pp. 1915-1918. ISSN 0031-9422

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A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:06
Last Modified: 22 Oct 2022 06:20
DOI: 10.1016/j.phytochem.2008.03.012

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