Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

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Stavri, Michael, Mathew, K.t., Gordon, Andrew, Shnyder, Steven D., Falconer, Robert A. and Gibbons, Simon (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. Phytochemistry, 69 (9). pp. 1915-1918. ISSN 0031-9422

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Abstract

A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	19 Jun 2020 00:06
Last Modified:	22 Oct 2022 06:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75685
DOI:	10.1016/j.phytochem.2008.03.012

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