Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

Das, Sharmistha, Yasmin, Hasina, Masud, M. Mehedi, Roy, Suvas C., Nahar, Lutfun, Rahman, M. Mukhlesur, Gibbons, Simon, Bachar, Sitesh C. and Sarker, Satyajit D. (2008) Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid. Tetrahedron, 64 (37). pp. 8642-8645. ISSN 0040-4020

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Abstract

6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:06
Last Modified: 10 Jul 2020 00:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/75680
DOI: 10.1016/j.tet.2008.07.010

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