Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

Tools

Das, Sharmistha, Yasmin, Hasina, Masud, M. Mehedi, Roy, Suvas C., Nahar, Lutfun, Rahman, M. Mukhlesur, Gibbons, Simon, Bachar, Sitesh C. and Sarker, Satyajit D. (2008) Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid. Tetrahedron, 64 (37). pp. 8642-8645. ISSN 0040-4020

Full text not available from this repository.

Abstract

6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	19 Jun 2020 00:06
Last Modified:	22 Oct 2022 06:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75680
DOI:	10.1016/j.tet.2008.07.010

Actions (login required)

View Item