Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation

Merinopoulos, Ioannis, Gunawardena, Tharusha, Stirrat, Colin, Cameron, Donnie, Eccleshall, Simon C., Dweck, Marc R., Newby, David E. and Vassiliou, Vassilios (2020) Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation. JACC: Cardiovascular Imaging. ISSN 1936-878X (In Press)

[img] PDF (Accepted_Manuscript) - Submitted Version
Restricted to Repository staff only until 31 December 2099.

Download (230kB) | Request a copy

Abstract

Cardiovascular magnetic resonance (CMR) is at the forefront of non-invasive methods for the assessment of myocardial anatomy, function and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recognition that inflammation plays a major role for various myocardial diseases such as myocardial infarction, myocarditis and takotsubo cardiomyopathy. Ultrasmall superparamagnetic particles of iron oxide (USPIO) are nanoparticles that are taken up by monocytes and macrophages accumulating at sites of inflammation. In this context, USPIO-enhanced CMR can provide valuable additional information regarding the cellular inflammatory component of myocardial and vascular diseases. Here, we will review the recent diagnostic applications of USPIO in terms of imaging myocardial and vascular inflammation, and highlight some of their future potential.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 09 Jun 2020 00:07
Last Modified: 09 Jul 2020 00:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/75506
DOI:

Actions (login required)

View Item View Item