Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation

Merinopoulos, Ioannis, Gunawardena, Tharusha, Stirrat, Colin, Cameron, Donnie, Eccleshall, Simon C., Dweck, Marc R., Newby, David E. and Vassiliou, Vassilios (2020) Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation. JACC: Cardiovascular Imaging. ISSN 1936-878X

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Abstract

Cardiac magnetic resonance (CMR) is at the forefront of noninvasive methods for the assessment of myocardial anatomy, function, and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recognition that inflammation plays a major role for various myocardial diseases such as myocardial infarction, myocarditis, and takotsubo cardiomyopathy. Ultrasmall superparamagnetic particles of iron oxide (USPIO) are nanoparticles that are taken up by monocytes and macrophages accumulating at sites of inflammation. In this context, USPIO-enhanced CMR can provide valuable additional information regarding the cellular inflammatory component of myocardial and vascular diseases. Here, we will review the recent diagnostic applications of USPIO in terms of imaging myocardial and vascular inflammation, and highlight some of their future potential.

Item Type: Article
Uncontrolled Keywords: cardiac magnetic resonance,inflammation,macrophage,ultrasmall superparamagnetic particles of iron oxide,radiology nuclear medicine and imaging,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2741
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 09 Jun 2020 00:07
Last Modified: 22 Sep 2020 00:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/75506
DOI: 10.1016/j.jcmg.2020.06.038

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