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Merinopoulos, Ioannis, Gunawardena, Tharusha, Stirrat, Colin, Cameron, Donnie 
ORCID: https://orcid.org/0000-0001-9841-6909, Eccleshall, Simon C., Dweck, Marc R., Newby, David E. and Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752
(2021)
Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation.
JACC: Cardiovascular Imaging, 14 (6).
pp. 1249-1264.
ISSN 1936-878X
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Abstract
Cardiac magnetic resonance (CMR) is at the forefront of noninvasive methods for the assessment of myocardial anatomy, function, and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recognition that inflammation plays a major role for various myocardial diseases such as myocardial infarction, myocarditis, and takotsubo cardiomyopathy. Ultrasmall superparamagnetic particles of iron oxide (USPIO) are nanoparticles that are taken up by monocytes and macrophages accumulating at sites of inflammation. In this context, USPIO-enhanced CMR can provide valuable additional information regarding the cellular inflammatory component of myocardial and vascular diseases. Here, we will review the recent diagnostic applications of USPIO in terms of imaging myocardial and vascular inflammation, and highlight some of their future potential.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cardiac magnetic resonance,inflammation,macrophage,ultrasmall superparamagnetic particles of iron oxide,radiology nuclear medicine and imaging,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2741 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 09 Jun 2020 00:07 |
| Last Modified: | 19 Oct 2023 02:42 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/75506 |
| DOI: | 10.1016/j.jcmg.2020.06.038 |
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