The MR-Base platform supports systematic causal inference across the human phenome

Hemani, Gibran, Zheng, Jie, Elsworth, Benjamin, Wade, Kaitlin H, Haberland, Valeriia ORCID: https://orcid.org/0000-0002-3874-0683, Baird, Denis, Laurin, Charles, Burgess, Stephen, Bowden, Jack, Langdon, Ryan, Tan, Vanessa Y, Yarmolinsky, James, Shihab, Hashem A, Timpson, Nicholas J, Evans, David M, Relton, Caroline, Martin, Richard M, Davey Smith, George, Gaunt, Tom R and Haycock, Philip C (2018) The MR-Base platform supports systematic causal inference across the human phenome. eLife, 7. ISSN 2050-084X

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Abstract

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base (<ext-link ext-link-type="uri" xlink:href="http://www.mrbase.org">http://www.mrbase.org</ext-link>): a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR. The software includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions. The database currently comprises 11 billion single nucleotide polymorphism-trait associations from 1673 GWAS and is updated on a regular basis. Integrating data with software ensures more rigorous application of hypothesis-driven analyses and allows millions of potential causal relationships to be efficiently evaluated in phenome-wide association studies.

Item Type:	Article
Additional Information:	© 2018, Hemani et al.
Uncontrolled Keywords:	metabolism,etiology,databases, genetic,genetic pleiotropy,genome-wide association study,humans,mendelian randomization analysis,models, genetic,phenotype,genetics
Depositing User:	LivePure Connector
Date Deposited:	06 May 2020 00:06
Last Modified:	02 Dec 2024 01:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75024
DOI:	10.7554/eLife.34408

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