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Steverding, Dietmar, Sidjui, Lazare S., Ferreira, Éden Ramalho, Ngameni, Bathelemy Ngameni, Folefoc, Gabriel N., Mahiou-Leddet, Valérie, Ollivier, Evelyne, Stephenson, G. Richard 
ORCID: https://orcid.org/0000-0003-1487-9178, Storr, Thomas and Tyler, Kevin ORCID: https://orcid.org/0000-0002-0647-8158
(2020)
Trypanocidal and leishmanicidal activity of six limonoids.
Journal of Natural Medicines, 74 (3).
606–611.
ISSN 1340-3443
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Abstract
Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma brucei and promastigotes of Leishmania major. Whereas all compounds showed anti-trypanosomal activity, only compounds 1–4 displayed anti-leishmanial activity. The 50% growth inhibition (GI 50) values for the trypanocidal and leishmanicidal activity of the compounds ranged between 2.5 and 14.9 μM. Kotschyienone A (1) was found to be the most active compound with a minimal inhibition concentration (MIC) value of 10 μM and GI 50 values between 2.5 and 2.9 μM. Only compounds 1 and 3 showed moderate cytotoxicity against HL-60 cells with MIC and GI 50 values of 100 μM and 31.5–46.2 μM, respectively. Compound 1 was also found to show activity against intracellular amastigotes of L. major with a GI 50 value of 1.5 μM. The results suggest that limonoids have potential as drug candidates for the development of new treatments against trypanosomiasis and leishmaniasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | african trypanosomiasis,blood-stream forms,leishmania major,leishmaniasis,limonoids,roots,trypanosoma-brucei,trypanosoma brucei |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Apr 2020 00:45 |
| Last Modified: | 25 Sep 2024 14:36 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/74708 |
| DOI: | 10.1007/s11418-020-01408-7 |
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