Diabetic ketoacidosis

Dhatariya, Ketan, Glaser, Nicole, Codner, Ethel and Umpierrez, Guillermo E. (2020) Diabetic ketoacidosis. Nature Reviews Disease Primers, 6. ISSN 2056-676X

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Abstract

Diabetic ketoacidosis (DKA) is the most common acute hyperglycaemic emergency in people with diabetes mellitus. A diagnosis of DKA is confirmed when all of the three criteria are present —‘D’, either elevated blood glucose levels or a family history of diabetes mellitus; ‘K’, the presence of high urinary or blood ketoacids; and ‘A’, a high anion gap metabolic acidosis. Early diagnosis and management is paramount to improve patient outcome. The mainstays of treatment include restoration of circulating volume, insulin therapy, electrolyte replacement and treatment of any underlying precipitating event. Without optimal treatment, DKA remains a condition with an appreciable, although largely preventable morbidity and mortality. In this Primer, we discuss the epidemiology, pathogenesis, risk factors and diagnosis of DKA, as well as we provide practical recommendations for management of DKA in adults and children.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 24 Mar 2020 01:53
Last Modified: 22 May 2020 00:21
URI: https://ueaeprints.uea.ac.uk/id/eprint/74610
DOI: 10.1038/s41572-020-0165-1

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