The role of diet in preventing and reducing cognitive decline

Angeloni, Cristina, Businaro, Rita and Vauzour, David (2020) The role of diet in preventing and reducing cognitive decline. Current Opinion in Psychiatry, 33 (4). pp. 432-438. ISSN 0951-7367

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Abstract

Purpose of review This review summarises the most recent evidence regarding the effects of diet in preventing and reducing age-related cognitive decline and neurodegenerative diseases. Recent findings Recent evidence indicates that nutraceuticals and whole diet approaches may protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects are diverse depending on the nutrient employed and may involve a reduction of neuroinflammation, an activation of the endogenous antioxidant defence system and a modulation of the gut microbiota structure and function. Summary This review summarises the existing evidence in favour of diet as a viable alternative approach to directly impact cognitive decline and neurodegenerative diseases. The single nutrient (polyphenols, B vitamins, long-chain polyunsaturated fatty acids) versus whole diet approach (Mediterranean diet, Dietary Approaches to Stop Hypertension, MIND, Nordic, ketogenic) is presented and discussed. Potential mechanisms of action underlying the beneficial effects of these diets are also described. Implementation of large-scale preventive interventions based on dietary patterns identified as being beneficial to brain health should be a research and public health priority, ideally in conjunction with other health-promoting lifestyle factors.

Item Type: Article
Uncontrolled Keywords: ageing,alzheimer’s disease,brain,dementia,nutrition
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 11 Mar 2020 10:31
Last Modified: 22 Aug 2020 00:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/74475
DOI: 10.1097/YCO.0000000000000605

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