Tools
Tools
Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703, Nicolau, David P., Hopkins, Katie L. and Meunier, Danièle
(2020)
Carbapenem-resistant enterobacterales, carbapenem resistant organisms, carbapenemase-producing enterobacterales, and carbapenemase-producing organisms:Terminology past its 'sell-by-date' in an era of new antibiotics and regional carbapenemase epidemiology.
Clinical Infectious Diseases, 71 (7).
1776–1782.
ISSN 1058-4838
Preview |
PDF (Accepted_Manuscript)
- Accepted Version
Download (256kB) | Preview |
Abstract
Carbapenem resistance in Gram-negative bacteria is a public health concern. Consequently, numerous government and agency reports discuss carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant organisms (CROs). Unfortunately, these terms are fuzzy. Do they include (1) Proteeae with inherent imipenem resistance; (2) porin-deficient Enterobacterales resistant to ertapenem but not other carbapenems; (3) Enterobacterales with OXA-48-like enzymes that remain "carbapenem susceptible" at breakpoint; and (4) Pseudomonas aeruginosa that merely lack porin OprD? Counting CPE or CPOs is better but still insufficient, because different carbapenemases have differing treatment implications, particularly for new β-lactam/β-lactamase inhibitor combinations. At the least, it is essential for authors, journals, and regulatory agencies to specify the carbapenemases meant. The future may demand even greater precision, for mutations can alter hydrolytic activity, and the ability to confer resistance, within carbapenemase families.
| Item Type: | Article |
|---|---|
| Additional Information: | Early title: 'CRE, CRO, CPE and CPO' |
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Feb 2020 08:29 |
| Last Modified: | 26 Jun 2024 11:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/74303 |
| DOI: | 10.1093/cid/ciaa122 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |