Stress-induced ATP release and growth modulation of human lens and retinal pigment epithelial cells

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Eldred, Julie A, Sanderson, Julie, Wormstone, Michael ORCID: https://orcid.org/0000-0002-6423-7766, Reddan, J. R. and Duncan, George (2002) Stress-induced ATP release and growth modulation of human lens and retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science, 43. ISSN 1552-5783

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Abstract

ATP release has been shown to occur following stimulation in several cellular systems. This study was undertaken to determine if lens and retinal epithelial cells release ATP in response to physiological stresses and to elucidate a possible role for ATP. Analysis of human aqueous humour samples showed a mean ATP level of 37.8+/-7.7 nM. Hyper-osmotic stress induced a dose- and time-dependent release of ATP. Both cell types were found to proliferate in serum-free medium, and the addition of ATP and adenosine at concentrations as low as 0.1 nM inhibited growth. Gene profiling also demonstrated the presence of the ectonucleotidases CD39 and CD73 and the A1 adenosine receptor on both cell types.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Science > Research Groups > Cells and Tissues
Related URLs:	https://iovs.arvojournals.org/article.as...
Depositing User:	LivePure Connector
Date Deposited:	12 Feb 2020 03:08
Last Modified:	24 Sep 2024 10:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/74147
DOI:

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