Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation

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Mdege, Noreen D., Man, Mei-See ORCID: https://orcid.org/0000-0003-4948-5670, Taylor, Celia A. and Torgerson, David J. (2011) Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation. Journal of Clinical Epidemiology, 64 (9). pp. 936-948. ISSN 0895-4356

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Abstract

Objective: To describe the application of the stepped wedge cluster randomized controlled trial (CRCT) design. Study Design and Setting: Systematic review. We searched Medline, Embase, PsycINFO, HMIC, CINAHL, Cochrane Library, Web of Knowledge, and Current Controlled Trials Register for articles published up to January 2010. Stepped wedge CRCTs from all fields of research were included. Two authors independently reviewed and extracted data from the studies. Results: Twenty-five studies were included in the review. Motivations for using the design included ethical, logistical, financial, social, and political acceptability and methodological reasons. Most studies were evaluating an intervention during routine implementation. For most of the included studies, there was also a belief or empirical evidence suggesting that the intervention would do more good than harm. There was variation in data analysis methods and insufficient quality of reporting. Conclusions: The stepped wedge CRCT design has been mainly used for evaluating interventions during routine implementation, particularly for interventions that have been shown to be effective in more controlled research settings, or where there is lack of evidence of effectiveness but there is a strong belief that they will do more good than harm. There is need for consistent data analysis and reporting.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:	http://europepmc.org/abstract/med/214112...
Depositing User:	LivePure Connector
Date Deposited:	28 Jan 2020 03:54
Last Modified:	24 Sep 2024 12:54
URI:	https://ueaeprints.uea.ac.uk/id/eprint/73841
DOI:	10.1016/j.jclinepi.2010.12.003

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