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Senghore, Madikay, Diarra, Bassirou, Gehre, Florian, Otu, Jacob, Worwui, Archibald, Muhammad, Abdul Khalie, Kwambana-Adams, Brenda, Kay, Gemma L., Sanogo, Moumine, Baya, Bocar, Orsega, Susan, Doumbia, Seydou, Diallo, Souleymane, de Jong, Bouke C., Pallen, Mark J. 
ORCID: https://orcid.org/0000-0003-1807-3657 and Antonio, Martin
(2020)
Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali.
Scientific Reports, 10.
ISSN 2045-2322
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Abstract
In recent years Bamako has been faced with an emerging threat from multidrug resistant TB (MDR-TB). Whole genome sequence analysis was performed on a subset of 76 isolates from a total of 208 isolates recovered from tuberculosis patients in Bamako, Mali between 2006 and 2012. Among the 76 patients, 61(80.3%) new cases and 15(19.7%) retreatment cases, 12 (16%) were infected by MDR-TB. The dominant lineage was the Euro-American lineage, Lineage 4. Within Lineage 4, the Cameroon genotype was the most prevalent genotype (n = 20, 26%), followed by the Ghana genotype (n = 16, 21%). A sub-clade of the Cameroon genotype, which emerged ~22 years ago was likely to be involved in community transmission. A sub-clade of the Ghana genotype that arose approximately 30 years ago was an important cause of MDR-TB in Bamako. The Ghana genotype isolates appeared more likely to be MDR than other genotypes after controlling for treatment history. We identified a clade of four related Beijing isolates that included one MDR-TB isolate. It is a major concern to find the Cameroon and Ghana genotypes involved in community transmission and MDR-TB respectively. The presence of the Beijing genotype in Bamako remains worrying, given its high transmissibility and virulence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | general,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1000 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Jan 2020 03:33 |
| Last Modified: | 31 Jan 2024 02:26 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/73779 |
| DOI: | 10.1038/s41598-019-56001-0 |
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