Associations with photoreceptor thickness measures in the UK Biobank

Chua, Sharon Y.L., Dhillon, Baljean, Aslam, Tariq, Balaskas, Konstantinos, Yang, Qi, Keane, Pearse A., Tufail, Adnan, Reisman, Charles, Foster, Paul J., Patel, Praveen J., Bishop, Prof Paul, Barman, Prof Sarah A., Barrett, Prof Jenny H., Blows, Mr Peter, Bunce, Dr Catey, Carare, Dr Roxana O., Chakravarthy, Prof Usha, Chan, Dr Michelle, Crabb, Prof David P., Cumberland, Mrs Philippa M., Day, Dr Alexander, Desai, Dr Parul, Sudlow, Prof Cathie, Dick, Prof Andrew D., Egan, Dr Cathy, Ennis, Prof Sarah, Fruttiger, Dr Marcus, Gallacher, Dr John E.J., Garway-Heath, Prof David F., Gibson, Dr Jane, Gore, Mr Dan, Guggenheim, Prof Jeremy A., Hammond, Prof Chris J., Hardcastle, Prof Alison, Harding, Prof Simon P., Hogg, Dr Ruth E., Hysi, Dr Pirro, Khaw, Prof Sir Peng T., Khawaja, Dr Anthony P., Lascaratos, Dr Gerassimos, Lotery, Prof Andrew J., Macgillivray, Dr Tom, Mackie, Dr Sarah, Martin, Prof Keith, Mcgaughey, Ms Michelle, Mcguinness, Dr Bernadette, Mckay, Dr Gareth J., Mckibbin, Mr Martin, Mitry, Dr Danny, Moore, Prof Tony and Yates, Max (2019) Associations with photoreceptor thickness measures in the UK Biobank. Scientific Reports, 9 (1). ISSN 2045-2322

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Abstract

Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

Item Type: Article
Uncontrolled Keywords: general ,/dk/atira/pure/subjectarea/asjc/1000
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 04 Jan 2020 04:08
Last Modified: 05 Jul 2020 23:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/73483
DOI: 10.1038/s41598-019-55484-1

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