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Chua, Sharon Y. L., Dhillon, Baljean, Aslam, Tariq, Balaskas, Konstantinos, Yang, Qi, Keane, Pearse A., Tufail, Adnan, Reisman, Charles, Foster, Paul J., Patel, Praveen J. and Yates, Max 
ORCID: https://orcid.org/0000-0003-3977-8920
and
UK Biobank Eye and Vision Consortium
(2019)
Associations with photoreceptor thickness measures in the UK Biobank.
Scientific Reports, 9.
ISSN 2045-2322
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Abstract
Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | general ,/dk/atira/pure/subjectarea/asjc/1000 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Jan 2020 04:08 |
| Last Modified: | 31 Jan 2024 02:24 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/73483 |
| DOI: | 10.1038/s41598-019-55484-1 |
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