Alien Domains Shaped the Modular Structure of Plant NLR Proteins

Andolfo, Giuseppe, Di Donato, Antimo, Chiaiese, Pasquale, De Natale, Antonino, Pollio, Antonino, Jones, Jonathan D G, Frusciante, Luigi and Ercolano, Maria Raffaella (2019) Alien Domains Shaped the Modular Structure of Plant NLR Proteins. Genome Biology and Evolution, 11 (12). pp. 3466-3477. ISSN 1759-6653

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Abstract

Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multitaxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the Viridiplantae. Our analysis points out that the basic NOD-like receptor (NLR) unit emerged in Chlorophytes by horizontal transfer and its diversification started from Toll/interleukin receptor-NB-LRR members. The operon-based genomic structure of Chromochloris zofingiensis NLR copies suggests a functional origin of NLR clusters. Moreover, the transmembrane signatures of NLR proteins in the unicellular alga C. zofingiensis support the hypothesis that the NLR-based immunity system of plants derives from a cell-surface surveillance system. Taken together, our findings suggest that NLRs originated in unicellular algae and may have a common origin with cell-surface LRR receptors.

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: LivePure Connector
Date Deposited: 03 Jan 2020 04:02
Last Modified: 25 Mar 2020 01:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/73465
DOI: 10.1093/gbe/evz248

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