Alien domains shaped the modular structure of plant NLR proteins

Andolfo, Giuseppe, Di Donato, Antimo, Chiaiese, Pasquale, De Natale, Antonino, Pollio, Antonino, Jones, Jonathan D G, Frusciante, Luigi and Ercolano, Maria Raffaella (2019) Alien domains shaped the modular structure of plant NLR proteins. Genome Biology and Evolution, 11 (12). pp. 3466-3477. ISSN 1759-6653

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Abstract

Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multitaxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the Viridiplantae. Our analysis points out that the basic NOD-like receptor (NLR) unit emerged in Chlorophytes by horizontal transfer and its diversification started from Toll/interleukin receptor-NB-LRR members. The operon-based genomic structure of Chromochloris zofingiensis NLR copies suggests a functional origin of NLR clusters. Moreover, the transmembrane signatures of NLR proteins in the unicellular alga C. zofingiensis support the hypothesis that the NLR-based immunity system of plants derives from a cell-surface surveillance system. Taken together, our findings suggest that NLRs originated in unicellular algae and may have a common origin with cell-surface LRR receptors.

Item Type:	Article
Additional Information:	© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	LivePure Connector
Date Deposited:	03 Jan 2020 04:02
Last Modified:	22 Oct 2022 05:39
URI:	https://ueaeprints.uea.ac.uk/id/eprint/73465
DOI:	10.1093/gbe/evz248

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