Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei

Chewapreecha, Claire, Mather, Alison E., Harris, Simon R., Hunt, Martin, Holden, Matthew T. G., Chaichana, Chutima, Wuthiekanun, Vanaporn, Dougan, Gordon, Day, Nicholas P. J., Limmathurotsakul, Direk, Parkhill, Julian and Peacock, Sharon J. (2019) Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei. Communications Biology, 2. ISSN 2399-3642

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Abstract

The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. Here, we performed genome-wide association studies for genetic determinants of environmental and human adaptation using a combined dataset of 1,010 whole genome sequences of B. pseudomallei from Northeast Thailand and Australia, representing two major disease hotspots. With these data, we identified 47 genes from 26 distinct loci associated with clinical or environmental isolates from Thailand and replicated 12 genes in an independent Australian cohort. We next outlined the selective pressures on the genetic loci (dN/dS) and the frequency at which they had been gained or lost throughout their evolutionary history, reflecting the bacterial adaptability to a wide range of ecological niches. Finally, we highlighted loci likely implicated in human disease.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.nature.com/articles/s42003-01...
Depositing User:	LivePure Connector
Date Deposited:	14 Dec 2019 03:22
Last Modified:	06 Jun 2024 15:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/73374
DOI:	10.1038/s42003-019-0678-x

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