Effects of a male meiotic driver on male and female transcriptomes in the house mouse

Lindholm, Anna, Sutter, Andreas, Künzel, Sven, Tautz, Diethard and Rehrauer, Hubert (2019) Effects of a male meiotic driver on male and female transcriptomes in the house mouse. Proceedings of the Royal Society B: Biological Sciences, 286 (1915). ISSN 0962-8452

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Abstract

Not all genetic loci follow Mendel's rules, and the evolutionary consequences of this are not yet fully known. Genomic conflict involving multiple loci is a likely outcome, as restoration of Mendelian inheritance patterns will be selected for, and sexual conflict may also arise when sexes are differentially affected. Here, we investigate effects of the t haplotype, an autosomal male meiotic driver in house mice, on genome-wide gene expression patterns in males and females. We analysed gonads, liver and brain in adult same-sex sibling pairs differing in genotype, allowing us to identify t-associated differences in gene regulation. In testes, only 40% of differentially expressed genes mapped to the approximately 708 annotated genes comprising the t haplotype. Thus, much of the activity of the t haplotype occurs in trans, and as upregulation. Sperm maturation functions were enriched among both cis and trans acting t haplotype genes. Within the t haplotype, we observed more downregulation and differential exon usage. In ovaries, liver and brain, the majority of expression differences mapped to the t haplotype, and were largely independent of the differences seen in the testis. Overall, we found widespread transcriptional effects of this male meiotic driver in the house mouse genome.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2019 02:02
Last Modified: 17 Oct 2020 23:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/73131
DOI: 10.1098/rspb.2019.1927

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