Molecular approaches to understanding transmission and source attribution in nontyphoidal Salmonella and their application in Africa

Mather, Alison E., Vaughan, Timothy G. and French, Nigel P. (2015) Molecular approaches to understanding transmission and source attribution in nontyphoidal Salmonella and their application in Africa. Clinical Infectious Diseases, 61 (suppl 4). S259-S265. ISSN 1058-4838

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Abstract

Nontyphoidal Salmonella (NTS) is a frequent cause of diarrhea around the world, yet in many African countries it is more commonly associated with invasive bacterial disease. Various source attribution models have been developed that utilize microbial subtyping data to assign cases of human NTS infection to different animal populations and foods of animal origin. Advances in molecular microbial subtyping approaches, in particular whole-genome sequencing, provide higher resolution data with which to investigate these sources. In this review, we provide updates on the source attribution models developed for Salmonella, and examine the application of whole-genome sequencing data combined with evolutionary modeling to investigate the putative sources and transmission pathways of NTS, with a focus on the epidemiology of NTS in Africa. This is essential information to decide where, what, and how control strategies might be applied most effectively.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	https://www.repository.cam.ac.uk/handle/... https://academic.oup.com/cid/article-loo...
Depositing User:	LivePure Connector
Date Deposited:	24 Apr 2019 11:30
Last Modified:	06 Jun 2024 15:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/70664
DOI:	10.1093/cid/civ727

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