Role of NF-κB pathway in the transition of mouse secondary follicles to antral follicles

Xu, Jun Jie, Wang, Guang, Luo, Xin, Wang, Li-Jing, Bao, Yongping and Yang, Xuesong (2019) Role of NF-κB pathway in the transition of mouse secondary follicles to antral follicles. Journal of Cellular Physiology, 234 (12). pp. 22565-22580. ISSN 0021-9541

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Abstract

NF-kappaB (NF-κB) signaling is involved in regulating a great number of normal and abnormal cellular events. However, little is known about its role in ovarian follicular development. In this study, we found NF-κB signaling is activated during the transition from secondary to antral follicles. We generated active NF-κB mice and found that antral follicular numbers were higher than wild-types ovaries. Activation of NF-κB signaling could enhance granulosa cell proliferation and regress granulosa cell apoptosis of mouse ovarian follicles. Higher FSHR and LHCGR expressions were observed in active NF-κB ovaries compared to wild-type. Furthermore, we confirmed that NF-κB signaling was indeed involved in the granulosa cell viability and proliferation through FSHR using COV434 cell line. This is the first experimental evidence that NF-κB signaling is implicated in the control of follicular development through FSHR and its corresponding target molecules, which might be achieved by targeting proliferation and apoptosis in follicular granulosa cells.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	16 Apr 2019 12:30
Last Modified:	28 Oct 2025 00:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/70598
DOI:	10.1002/jcp.28822

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