The gut microbiota and the hepatologist: Will our bugs prove to be the missing link?

Pallen, Mark J. ORCID: https://orcid.org/0000-0003-1807-3657 and Quraishi, Mohammed N. (2017) The gut microbiota and the hepatologist: Will our bugs prove to be the missing link? Digestive Diseases, 35 (4). pp. 377-383. ISSN 0257-2753

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Abstract

The advent of next-generation sequencing has enabled in-depth analysis to study the composition and function of the gut microbiota in a culture-independent manner. Consequently, this has led to rapid interest in understanding the pathogenesis and progression of chronic liver disease in relation to perturbations of the gut microbiota. Animal models and human studies have demonstrated its crucial role in contributing to disease mechanisms in alcoholic and non-alcoholic liver disease and more recently in primary sclerosing cholangitis. There is increasing evidence to suggest that the gut microbiota and its components influence the development and modulation of chronic liver damage through direct communication via the portal system, metabolite production, alterations in gut barrier integrity, liver/gut immune axis and bile acid metabolism. The impact of microbiota-directed therapies for liver disease is still in its infancy. Better understanding of its role in disease mechanisms will lead to a more targeted approach in modulation of gut microbiota to influence both progression and complications of liver disease. This review discusses the current evidence for the gut microbiota-liver axis and its role in the development, progression and treatment of liver disease.

Item Type:	Article
Additional Information:	© 2017 S. Karger AG, Basel.
Uncontrolled Keywords:	animals,disease progression,gastroenterologists,gastrointestinal microbiome,humans,microbiology,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	LivePure Connector
Date Deposited:	18 Mar 2019 14:30
Last Modified:	04 Mar 2024 17:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/70261
DOI:	10.1159/000456590

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