Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Feldmann, M, Andreakos, E, Smith, C, Bondeson, J, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, S, Lundberg, A, Paleolog, E, Horwood, N J ORCID:, Brennan, F M and Foxwell, B M J (2002) Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases, 61 (Suppl 2). ii13-ii18. ISSN 0003-4967

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There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Item Type: Article
Uncontrolled Keywords: genetics,antigen presentation,immunology,cell culture techniques,immunology,genetic vectors,humans,genetics,immunity, cellular,lymphocyte culture test, mixed,antagonists & inhibitors,immunology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: LivePure Connector
Date Deposited: 06 Mar 2019 12:30
Last Modified: 19 Oct 2023 02:22
DOI: 10.1136/ard.61.suppl_2.ii13

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