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Feldmann, M, Andreakos, E, Smith, C, Bondeson, J, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, S, Lundberg, A, Paleolog, E, Horwood, N J 
ORCID: https://orcid.org/0000-0002-6344-1677, Brennan, F M and Foxwell, B M J
(2002)
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the Rheumatic Diseases, 61 (Suppl 2).
ii13-ii18.
ISSN 0003-4967
Abstract
There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | genetics,antigen presentation,immunology,cell culture techniques,immunology,genetic vectors,humans,genetics,immunity, cellular,lymphocyte culture test, mixed,antagonists & inhibitors,immunology |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | LivePure Connector |
| Date Deposited: | 06 Mar 2019 12:30 |
| Last Modified: | 25 Sep 2024 13:57 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/70160 |
| DOI: | 10.1136/ard.61.suppl_2.ii13 |
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