Alarmins:awaiting a clinical response

Chan, James K, Roth, Johannes, Oppenheim, Joost J, Tracey, Kevin J, Vogl, Thomas, Feldmann, Marc, Horwood, Nicole and Nanchahal, Jagdeep (2012) Alarmins:awaiting a clinical response. Journal of Clinical Investigation, 122 (8). pp. 2711-2719. ISSN 0021-9738

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Abstract

Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

Item Type: Article
Uncontrolled Keywords: adaptive immunity,animals,immunology,biomarkers,humans,immunity, innate,immunology,immunology,immunology,regenerative medicine,immunology,signal transduction,immunology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 06 Mar 2019 11:30
Last Modified: 25 Jul 2019 02:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/70147
DOI: 10.1172/JCI62423

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