Chan, James K, Roth, Johannes, Oppenheim, Joost J, Tracey, Kevin J, Vogl, Thomas, Feldmann, Marc, Horwood, Nicole ORCID: https://orcid.org/0000-0002-6344-1677 and Nanchahal, Jagdeep (2012) Alarmins:awaiting a clinical response. Journal of Clinical Investigation, 122 (8). pp. 2711-2719. ISSN 0021-9738
Full text not available from this repository. (Request a copy)Abstract
Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.
Item Type: | Article |
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Uncontrolled Keywords: | adaptive immunity,animals,immunology,biomarkers,humans,immunity, innate,immunology,immunology,immunology,regenerative medicine,immunology,signal transduction,immunology,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
Depositing User: | LivePure Connector |
Date Deposited: | 06 Mar 2019 11:30 |
Last Modified: | 25 Sep 2024 13:58 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/70147 |
DOI: | 10.1172/JCI62423 |
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