Development of micron and submicron scale carriers for drugs and nutrients delivery

Rustem Kyzy, Cholpon (2018) Development of micron and submicron scale carriers for drugs and nutrients delivery. Doctoral thesis, University of East Anglia.

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Abstract

Formulating multiple nutrient supplements and better dosage forms for paediatric patients are still current needs and challenges. This study aims to develop a cost-effective novel delivery system capable of delivering water-soluble and oil-soluble nutrients or drugs to address paediatric compliance. Two ranges of micron and submicron scale carriers for nutrients and drugs were developed and characterized thoroughly. First, fast-dissolving orodispersible film was produced using an emerging electrospinning technique to deliver iodine, an essential micronutrient. PEO and KIO3 were used in a formulation that ensures the safety and cost-effectiveness of the final product. Second, a novel structured oil system (SOS), capable of holding a large amount of oil, was designed as a carrier for fat-soluble vitamins and drugs. This SOS was produced using a freeze dryer that is suitable for heat sensitive vitamins and drugs. Gelatine/Xanthangum were used as emulsifiers due to the affinity of protein-polysaccharide complexes to form emulsions stable to environmental stresses such as freezing. In addition, a range of SOSs were formulated using Hypromellose/Xanthangum, Methylcellulose/Xanthangum, Tween 20/Xanthangum, and Gelatine/Carboxymethylcellulose in order to understand the formation of SOS, to prove the concept that any surface active and non-surface active polymers that can form electrostatic complexes can form SOS, and to find an alternative to Gelatine/Xanthangum emulsifiers. A thorough physicochemical characterisation of both the fast-dissolving orodispersible film and structured oil systems was conducted using a range of analytical techniques including imaging techniques (various optical and electron microscopes, and XμCT), ATR-FTIR, PXRD, DSC, TGA, a texture analyser, LD, and in vitro dissolution testing.
This study demonstrated that electrospinning technology has great potential to be used in formulating a dosage form for children, that liquid vegetable oil and fish oil can be encapsulated within fibres using emulsion electrospinning and introduced a novel solid structured oil system capable of holding large amounts of oil.

Item Type:	Thesis (Doctoral)
Faculty \ School:	Faculty of Science > School of Pharmacy
Depositing User:	Jackie Webb
Date Deposited:	12 Feb 2019 11:32
Last Modified:	12 Feb 2019 11:39
URI:	https://ueaeprints.uea.ac.uk/id/eprint/69909
DOI:

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