Sleep and cognitive ageing in the 8th decade of life

Cox, Simon R., Ritchie, Stuart J., Allerhand, Mike, Hagenaars, Saskia P., Radakovic, Ratko, Breen, David P., Davies, Gail, Riha, Renata L., Harris, Sarah E., Starr, John M. and Deary, Ian J. (2019) Sleep and cognitive ageing in the 8th decade of life. Sleep, 42 (4). ISSN 0161-8105

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Abstract

We examined associations between self-reported sleep measures and cognitive level and change (age 70-76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1,091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = -0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = -0.009, SE = 0.003, p = 0.008), and processing speed (β = -0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardised β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.

Item Type:	Article
Additional Information:	Funding information: The LBC1936 and this research are supported by Age UK (Disconnected Mind project) and by the UK Medical Research Council (MRC; G0701120, G1001245, MR/M013111/1; MR/R024065/1). R.R. is funded by the Motor Neurone Disease Association and Motor Neurone Disease Scotland. This work was undertaken within The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (www.ccace.ed.ac.uk), funded by the MRC and the Biotechnology and Biological Sciences Research Council (MR/K026992/1). This report represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Depositing User:	LivePure Connector
Date Deposited:	07 Feb 2019 11:30
Last Modified:	11 Nov 2024 00:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/69874
DOI:	10.1093/sleep/zsz019

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