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Tanner, Jennifer R. and Kingsley, Robert A. 
ORCID: https://orcid.org/0000-0002-0194-6485
(2018)
Evolution of Salmonella within hosts.
Trends in Microbiology, 26 (12).
pp. 986-998.
ISSN 0966-842X
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Abstract
Within-host evolution has resulted in thousands of variants of Salmonella that exhibit remarkable diversity in host range and disease outcome, from broad host range to exquisite host restriction, causing gastroenteritis to disseminated disease such as typhoid fever. Within-host evolution is a continuing process driven by genomic variation that occurs during each infection, potentiating adaptation to a new niche resulting from changes in animal husbandry, the use of antimicrobials, and emergence of immune compromised populations. We discuss key advances in our understanding of the evolution of Salmonella within the host, inferred from (i) the process of host adaptation of Salmonella pathovars in the past, and (ii) direct observation of the generation of variation and selection of beneficial traits during single infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adaptation,evolution,pathogenesis,salmonella,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 31 Jan 2019 16:30 |
| Last Modified: | 05 Jul 2023 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/69782 |
| DOI: | 10.1016/j.tim.2018.06.001 |
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