Tools
ToolsHalstead, Fenella D, Rauf, Maryam, Bamford, Amy, Wearn, Christopher M, Bishop, Jonathan R B, Burt, Rebecca, Fraise, Adam P, Moiemen, Naiem S, Oppenheim, Beryl A and Webber, Mark A (2015) Antimicrobial dressings: Comparison of the ability of a panel of dressings to prevent biofilm formation by key burn wound pathogens. Burns, 41 (8). pp. 1683-1694. ISSN 0305-4179
Full text not available from this repository. (Request a copy)Abstract
UNLABELLED: Antimicrobial medicated dressings (AMD) are often used to reduce bacterial infection of burns and other wounds. However, there is limited literature regarding comparative efficacies to inform effective clinical decision making. OBJECTIVES: Following on from a previous study where we demonstrated good antibiofilm properties of acetic acid (AA), we assessed and compared the in vitro anti-biofilm activity of a range of AMDs and non-AMDs to AA. METHODS: Laboratory experiments determined the ability of a range of eleven commercial AMD, two nAMD, and AA, to prevent the formation of biofilms of a panel of four isolates of Pseudomonas aeruginosa and Acinetobacter baumannii. RESULTS: There is a large variation in ability of different dressings to inhibit biofilm formation, seen between dressings that contain the same, and those that contain other antimicrobial agents. The best performing AMD were Mepilex(®) Ag and Acticoat. AA consistently prevented biofilm formation. CONCLUSIONS: Large variation exists in the ability of AMD to prevent biofilm formation and colonisation of wounds. A standardised in vitro methodology should be developed for external parties to examine and compare the efficacies of commercially available AMDs, along with robust clinical randomised controlled trials. This is essential for informed clinical decision-making and optimal patient management.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved. |
| Uncontrolled Keywords: | pharmacology,prevention & control,drug effects,pharmacology,bandages,drug effects,microbiology,pharmacology,honey,in vitro techniques,pharmacology,microbial sensitivity tests,therapeutic use,therapeutic use,prevention & control,drug effects,pharmacology,prevention & control |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Jan 2019 13:30 |
| Last Modified: | 21 Oct 2022 21:33 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/69576 |
| DOI: | 10.1016/j.burns.2015.06.005 |
Actions (login required)
 |
View Item |