Heparan sulfate as a regulator of inflammation and immunity

Collins, Laura E and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2019) Heparan sulfate as a regulator of inflammation and immunity. Journal of Leukocyte Biology, 105 (1). pp. 81-92. ISSN 0741-5400

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Abstract

Heparan sulfate is found on the surface of most cell types, as well as in basement membranes and extracellular matrices. Its strong anionic properties and highly variable structure enable this glycosaminoglycan to provide binding sites for numerous protein ligands, including many soluble mediators of the immune system, and may promote or inhibit their activity. The formation of ligand binding sites on heparan sulfate (HS) occurs in a tissue- and context-specific fashion through the action of several families of enzymes, most of which have multiple isoforms with subtly different specificities. Changes in the expression levels of these biosynthetic enzymes occur in response to inflammatory stimuli, resulting in structurally different HS and acquisition or loss of binding sites for immune mediators. In this review, we discuss the multiple roles for HS in regulating immune responses, and the evidence for inflammation-associated changes to HS structure.

Item Type:	Article
Additional Information:	©2018 Society for Leukocyte Biology.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	https://ora.ox.ac.uk/objects/uuid:5c19a0...
Depositing User:	LivePure Connector
Date Deposited:	08 Jan 2019 09:30
Last Modified:	19 Oct 2023 02:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/69461
DOI:	10.1002/JLB.3RU0618-246R

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