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Radakovic, Ratko, Puthusseryppady, Vaisakh, Flanagan, Emma, Kiernan, Matthew C., Mioshi, Eneida and Hornberger, Michael 
ORCID: https://orcid.org/0000-0002-2214-3788
(2018)
Frontostriatal grey matter atrophy in amyotrophic lateral sclerosis A visual rating study.
Dementia & Neuropsychologia, 12 (4).
pp. 388-393.
ISSN 1980-5764
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Abstract
Background: Amyotrophic lateral sclerosis (ALS) is characterised by frontostriatal grey matter changes similar to those in frontotemporal dementia (FTD). However, these changes are usually detected at a group level, and simple visual magnetic resonance imaging (MRI) cortical atrophy scales may further elucidate frontostriatal changes in ALS. Objective: To investigate whether frontostriatal changes are detectable using simple visual MRI atrophy rating scales applied at an individual patient level in ALS. Methods: 21 ALS patients and 17 controls were recruited and underwent an MRI scan. Prefrontal cortex sub-regions of the medial orbitofrontal cortex (MOFC), lateral orbitofrontal cortex (LOFC) and anterior cingulate cortex (ACC), striatal sub-regions of the caudate nucleus (CN) and nucleus accumbens (NAcc) were rated using visual grey matter atrophy 5-point Likert scales. Results: Significantly higher atrophy ratings in the bilateral MOFC in ALS patients versus controls was only observed (p<.05). Patients with higher MOFC atrophy had significantly higher atrophy of the CN (p<.05) and LOFC (p<.05). Conclusions: Use of simple visual atrophy rating scales on an individual level reliably detects frontostriatal deficits specific to ALS, showing MOFC atrophy differences with associated CN and LOFC atrophy. This is an applicable method that could be used to support clinical diagnosis and management.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 21 Dec 2018 12:30 |
| Last Modified: | 06 Jun 2024 15:04 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/69425 |
| DOI: | 10.1590/1980-57642018dn12-040008 |
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