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Jennings, Amy, Berendsen, Agnes A. M., de Groot, Lisette C. P. G. M., Feskens, Edith J M, Brzozowska, Anna, Sicinska, Ewa, Pietruszka, Barbara, Meunier, Nathalie, Caumon, Elodie, Malpuech-Brugere, Corinne, Santoro, Aurelia, Ostan, Rita, Franceschi, Claudio, Gillings, Rachel, O'Neill, Colette, Fairweather-Tait, Susan 
ORCID: https://orcid.org/0000-0002-1413-5569, Minihane, Anne-Marie ORCID: https://orcid.org/0000-0001-9042-4226 and Cassidy, Aedin
(2019)
Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults: Results of a 1-year European multi-center trial.
Hypertension, 73 (3).
578–586.
ISSN 0194-911X
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Abstract
We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P=0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aging,blood pressure,potassium,pulse wave velocity,sodium,internal medicine ,/dk/atira/pure/subjectarea/asjc/2700/2724 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Dec 2018 16:31 |
| Last Modified: | 19 Oct 2023 02:19 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/69413 |
| DOI: | 10.1161/HYPERTENSIONAHA.118.12259 |
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