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Shi, Ying, Kellingray, Lee, Le Gall, Gwenaelle 
ORCID: https://orcid.org/0000-0002-1379-2196, Zhao, Jianxin, Zhang, Hao, Narbad, Arjan, Zhai, Qixiao and Chen, Wei
(2018)
The divergent restoration effects of Lactobacillus strains in antibiotic-induced dysbiosis.
Journal of Functional Foods, 51.
pp. 142-152.
ISSN 1756-4646
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Abstract
To evaluate functions of Lactobacillus strains, isolated from fermented food, in restoration of ampicillin-induced disruption based on mucosal barrier, gut microbial community and metabolome analyses, three Lactobacillus strains, L. plantarum CGMCC12436 (LacP), L. casei CGMCC 12,435 (LacC) and L. rhamnosus strain GG (LacG) were individually administered to ampicillin-pretreated mice. All three strains significantly restored concentrations of endotoxin and diamine oxidase to control levels. Linear discriminate analysis based on 16S rRNA sequencing of faecal bacteria revealed that the restoration of microbial communities by Lactobacillus strains was more effective than natural restoration. Correlation analysis between microbiota and metabolites indicated that, the higher level of acetate in LacC group was positively correlated with increased relative abundance of Citrobacter, Bifidobacterium and S24-7. Furthermore, LacC down-regulated the expression of NF-κB p65 and modulated the ampicillin-induced inflammatory responses. The LacC strain could particularly attenuate ampicillin-induced disruption by optimisation of microbial taxa and enhancement of acetate and butyrate production.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | functional food,gut dysbiosis,immunity,metabolites,microbial ecology,food science,medicine (miscellaneous),nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/1100/1106 |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Nov 2018 16:30 |
| Last Modified: | 22 Oct 2022 04:14 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/68925 |
| DOI: | 10.1016/j.jff.2018.10.011 |
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