Offspring metabolomic response to maternal protein restriction in a rat model of Intrauterine Growth Restriction (IUGR)

Alexandre-Gouabau, Marie Cécile, Courant, Frédérique, Le Gall, Gwénaeìlle ORCID: https://orcid.org/0000-0002-1379-2196, Moyon, Thomas, Darmaun, Dominique, Parnet, Patricia, Coupé, Bérengère and Antignac, Jean-Philippe (2011) Offspring metabolomic response to maternal protein restriction in a rat model of Intrauterine Growth Restriction (IUGR). Journal of Proteome Research, 10 (7). pp. 3292-3302. ISSN 1535-3893

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Abstract

Intrauterine growth restriction (IUGR), along with postnatal growth trajectory, is closely linked with metabolic diseases and obesity at adulthood. The present study reports the time-dependent metabolomic response of male offspring of rat dams exposed to maternal adequate protein diet during pregnancy and lactation (CC) or protein deprivation during pregnancy only (IUGR with rapid catch-up growth, RC) or through pregnancy and lactation (IUGR with slow postnatal growth, RR). Plasma LC-HRMS metabolomic fingerprints for 8 male rats per group, combined with multivariate statistical analysis (PLS-DA and HCA), were used to study the impact of IUGR and postnatal growth velocity on the offspring metabolism in early life (until weaning) and once they reached adulthood (8 months). Compared with CC rats, RR pups had clear-cut alterations in plasma metabolome during suckling, but none at adulthood; in contrast, in RC pups, alterations in metabolome were minimal in early life but more pronounced in the long run. In particular, our results pinpoint transient alterations in proline, arginine, and histidine in RR rats, compared to CC rats, and persistent differences in tyrosine and carnitine, compared to RC rats at adulthood. These findings suggest that the long-term deregulation in feeding behavior and fatty acid metabolism in IUGR rats depends on postnatal growth velocity.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,chemistry(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	26 Oct 2018 15:30
Last Modified:	25 May 2023 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68674
DOI:	10.1021/pr2003193

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