Specifying a causal role for angular gyrus in autobiographical memory

Bonnici, Heidi M., Cheke, Lucy G., Green, Deborah A.E., FitzGerald, Thomas H.B. ORCID: https://orcid.org/0000-0002-3855-1591 and Simons, Jon S. (2018) Specifying a causal role for angular gyrus in autobiographical memory. The Journal of Neuroscience, 38 (49). pp. 10438-10443. ISSN 0270-6474

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Abstract

Considerable recent evidence indicates that angular gyrus dysfunction in humans does not result in amnesia, but does impair a number of aspects of episodic memory. Patients with parietal lobe lesions have been reported to exhibit a deficit when freely recalling autobiographical events from their pasts, but can remember details of the events when recall is cued by specific questions. In apparent contradiction, inhibitory brain stimulation targeting angular gyrus in healthy volunteers has been found to have no effect on free recall or cued recall of word pairs. The present study sought to resolve this inconsistency by testing free and cued recall of both autobiographical memories and word pair memories in the same healthy male and female human participants following continuous theta burst stimulation (cTBS) of angular gyrus and a vertex control location. Angular gyrus cTBS resulted in a selective reduction in the free recall but not cued recall of autobiographical memories, whereas free and cued recall of word pair memories were unaffected. Additionally, participants reported fewer autobiographical episodes as being experienced from a first-person perspective following angular gyrus cTBS. The findings add to a growing body of evidence that a function of angular gyrus within the network of brain regions responsible for episodic recollection is to integrate memory features within an egocentric framework into the kind of first-person perspective representation that enables the subjective experience of remembering events from our personal pasts.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Cognition, Action and Perception
Depositing User:	LivePure Connector
Date Deposited:	12 Oct 2018 00:05
Last Modified:	09 Mar 2024 01:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68474
DOI:	10.1101/323733

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