Osteoprotegerin and myocardial fibrosis in patients with aortic stenosis

Loudon, Brodie L., Ntatsaki, Eleana, Newsome, Simon, Halliday, Brian, Lota, Amrit, Ali, Aamir, Malley, Tamir, Selvendran, Subothini, Aggarwal, Nikhil, Lam, Willis, Donovan, Jackie, Auger, Dominque, Raphael, Claire E., Flynn, Paul D., Pennell, Dudley J., Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 and Prasad, Sanjay K. (2018) Osteoprotegerin and myocardial fibrosis in patients with aortic stenosis. Scientific Reports, 8. ISSN 2045-2322

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Abstract

Left ventricular myocardial fibrosis in patients with aortic stenosis (AS) confers worse prognosis. Plasma osteoprotegerin (OPG), a cytokine from the TNF receptor family, correlates with the degree of valve calcification in AS, reflecting the activity of the tissue RANKL/RANK/OPG (receptor activator of nuclear factor κΒ ligand/RANK/osteoprotegerin) axis, and is associated with poorer outcomes in AS. Its association with myocardial fibrosis is unknown. We hypothesised that OPG levels would reflect the extent of myocardial fibrosis in AS. We included 110 consecutive patients with AS who had undergone late-gadolinium contrast enhanced cardiovascular magnetic resonance (LGE-CMR). Patients were characterised according to pattern of fibrosis (no fibrosis, midwall fibrosis, or chronic myocardial infarction fibrosis). Serum OPG was measured with ELISA and compared between groups defined by valve stenosis severity. Some 36 patients had no fibrosis, 38 had midwall fibrosis, and 36 had chronic infarction. Patients with midwall fibrosis did not have higher levels of OPG compared to those without fibrosis (6.78 vs. 5.25 pmol/L, p = 0.12). There was no difference between those with midwall or chronic myocardial infarction fibrosis (6.78 vs. 6.97 pmol/L, p = 0.27). However, OPG levels in patients with chronic myocardial infarction fibrosis were significantly higher than those without fibrosis (p = 0.005).

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	08 Oct 2018 10:30
Last Modified:	19 Oct 2023 02:17
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68422
DOI:	10.1038/s41598-018-32738-y

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