Nanocrystallization of rare tolbutamide form V in mesoporous MCM-41 silica

Tools

Nartowski, Karol, Malhotra, Diksha, Hawarden, Lucy, Fabian, Laszlo and Khimyak, Yaroslav ORCID: https://orcid.org/0000-0003-0424-4128 (2018) Nanocrystallization of rare tolbutamide form V in mesoporous MCM-41 silica. Molecular Pharmaceutics, 15 (11). 4926–4932. ISSN 1543-8384

[thumbnail of Accepted manuscript]
Preview
 PDF (Accepted manuscript) - Accepted Version
Download (1MB) | Preview

Abstract

Encapsulation of pharmaceuticals inside nanoporous materials is of increasing interest due to their possible applications as new generation therapeutics, theranostic platforms, or smart devices. Mesoporous silicas are leading materials to be used as nanohosts for pharmaceuticals. Further development of new generation of nanoscale therapeutics requires complete understanding of the complex host−guest interactions of organic molecules confined in nanosized chambers at different length scales. In this context, we present results showing control over formation and phase transition of nanosize crystals of model flexible pharmaceutical molecule tolbutamide confined inside 3.2 nm pores of the MCM-41 host. Using low loading levels (up to 30 wt %), we were able to stabilize the drug in highly dynamic amorphous/disordered state or direct the crystallization of the drug into highly metastable nanocrystalline form V of tolbutamide (at loading levels of 40 and 50 wt %), providing first experimental evidence for crystallization of pharmaceuticals inside the pores as narrow as 3.2 nm.

Item Type: Article
Uncontrolled Keywords: drug delivery,encapsulation,mesoporous silica,polymorphism,solid-state nmr,tolbutamide
Faculty \ School: Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups: Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User: LivePure Connector
Date Deposited: 03 Oct 2018 15:30
Last Modified: 17 Oct 2024 00:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/68413
DOI: 10.1021/acs.molpharmaceut.8b00575

Downloads

Downloads per month over past year

Actions (login required)

View Item View Item