Pathogen perception by NLRs in plants and animals: Parallel worlds

Duxbury, Zane, Ma, Yan, Furzer, Oliver, Huh, Sung Un, Cevik, Volkan, Jones, Jonathan and Sarris, Panagiotis (2016) Pathogen perception by NLRs in plants and animals: Parallel worlds. BioEssays, 38 (8). pp. 769-781. ISSN 0265-9247

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Abstract

Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.

Item Type:	Article
Uncontrolled Keywords:	animals,effectors,innate immunity,nlr,plants,receptors
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	LivePure Connector
Date Deposited:	12 Sep 2018 15:30
Last Modified:	22 Oct 2022 04:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68262
DOI:	10.1002/bies.201600046

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