An update on the human and animal enteric pathogen Clostridium perfringens

Kiu, Raymond and Hall, Lindsay J. (2018) An update on the human and animal enteric pathogen Clostridium perfringens. Emerging Microbes & Infections, 7. ISSN 2222-1751

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Abstract

Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century. Recent advances in genomic analysis and experimental systems make it timely to re-visit this clinically and veterinary important pathogen. This Review will summarise our understanding of the genomics and virulence-linked factors, including antimicrobial potentials and secreted toxins of this gut pathogen, and then its up-to-date clinical epidemiology and biological role in the pathogenesis of several important human and animal-associated intestinal diseases, including pre-term necrotising enterocolitis. Finally, we highlight some of the important unresolved questions in relation to C. perfringens-mediated infections, and implications for future research directions.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 20 Aug 2018 12:30
Last Modified: 09 Sep 2020 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/68090
DOI: 10.1038/s41426-018-0144-8

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