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Kiu, Raymond and Hall, Lindsay J. 
ORCID: https://orcid.org/0000-0001-8938-5709
(2018)
An update on the human and animal enteric pathogen Clostridium perfringens.
Emerging Microbes & Infections, 7.
ISSN 2222-1751
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Abstract
Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century. Recent advances in genomic analysis and experimental systems make it timely to re-visit this clinically and veterinary important pathogen. This Review will summarise our understanding of the genomics and virulence-linked factors, including antimicrobial potentials and secreted toxins of this gut pathogen, and then its up-to-date clinical epidemiology and biological role in the pathogenesis of several important human and animal-associated intestinal diseases, including pre-term necrotising enterocolitis. Finally, we highlight some of the important unresolved questions in relation to C. perfringens-mediated infections, and implications for future research directions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Aug 2018 12:30 |
| Last Modified: | 21 Oct 2022 19:36 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/68090 |
| DOI: | 10.1038/s41426-018-0144-8 |
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