Di Sabatino, Antonio, Biancheri, Paolo, Rovedatti, Laura, MacDonald, Thomas T and Corazza, Gino R (2012) New pathogenic paradigms in inflammatory bowel disease. Inflammatory Bowel Diseases, 18 (2). pp. 368-371. ISSN 1078-0998
Full text not available from this repository.Abstract
Recent progresses in basic science have opened new pathogenic scenarios in inflammatory bowel disease. The T helper cell type (Th)1/Th2 paradigm has been outdated thanks to the advances in understanding the function of Th17 cells. Innate immunity, nonimmune cells, and defective tolerogenic mechanisms play a no less crucial role than do adaptive immunity, immune cells, and hyperactivation of effector mechanisms. These new paradigms, together with the no longer "static" but "dynamic" vision of intestinal inflammation, highlight new possible therapeutic targets in inflammatory bowel disease.
Item Type: | Article |
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Additional Information: | Copyright © 2011 Crohn's & Colitis Foundation of America, Inc. |
Uncontrolled Keywords: | adaptive immunity,humans,immune tolerance,immunity, innate,immunity, mucosal,immunology,immunology,immunology,immunology,immunology,immunology |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
Depositing User: | LivePure Connector |
Date Deposited: | 07 Aug 2018 16:30 |
Last Modified: | 22 Oct 2022 04:03 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/67990 |
DOI: | 10.1002/ibd.21735 |
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