Innate and adaptive immunity in inflammatory bowel disease

Geremia, Alessandra, Biancheri, Paolo, Allan, Philip, Corazza, Gino R and Di Sabatino, Antonio (2014) Innate and adaptive immunity in inflammatory bowel disease. Autoimmunity Reviews, 13 (1). pp. 3-10. ISSN 1568-9972

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Abstract

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). The exact cause of IBD remains unknown. Available evidence suggests that an abnormal immune response against the microorganisms of the intestinal flora is responsible for the disease in genetically susceptible individuals. The adaptive immune response has classically been considered to play a major role in the pathogenesis of IBD. However, recent advances in immunology and genetics have clarified that the innate immune response is equally as important in inducing gut inflammation in these patients. In particular, an altered epithelial barrier function contributes to intestinal inflammation in patients with UC, while aberrant innate immune responses, such as antimicrobial peptide production, innate microbial sensing and autophagy are particularly associated to CD pathogenesis. On the other hand, besides T helper cell type (Th)1 and Th2 immune responses, other subsets of T cells, namely Th17 and regulatory T (Treg) cells, are likely to play a role in IBD. However, given the complexity and probably the redundancy of pathways leading to IBD lesions, and the fact that Th17 cells may also have protective functions, neutralization of IL-17A failed to induce any improvement in CD. Studying the interactions between various constituents of the innate and adaptive immune systems will certainly open new horizons in the knowledge about the immunologic mechanisms implicated in gut inflammation.

Item Type:	Article
Additional Information:	Copyright © 2013 Elsevier B.V. All rights reserved.
Uncontrolled Keywords:	adaptive immunity,genetic predisposition to disease,humans,immunology,immunity, innate,genetics,immunology
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	LivePure Connector
Date Deposited:	07 Aug 2018 16:30
Last Modified:	21 Oct 2022 19:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/67982
DOI:	10.1016/j.autrev.2013.06.004

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