One-year consumption of a Mediterranean-like dietary pattern with vitamin D3 supplements induced small scale but extensive changes of immune cell phenotype, co-receptor expression and innate immune responses in healthy elderly subjects:Results from the United Kingdom arm of the NU-AGE trial

Maijo, Monica, Ivory, Kamal, Clements, Sarah J, Dainty, Jack R ORCID: https://orcid.org/0000-0002-0056-1233, Jennings, Amy, Gillings, Rachel, Fairweather-Tait, Susan ORCID: https://orcid.org/0000-0002-1413-5569, Gulisano, Massimo, Santoro, Aurelia, Franceschi, Claudio, Carding, Simon R and Nicoletti, Claudio (2018) One-year consumption of a Mediterranean-like dietary pattern with vitamin D3 supplements induced small scale but extensive changes of immune cell phenotype, co-receptor expression and innate immune responses in healthy elderly subjects:Results from the United Kingdom arm of the NU-AGE trial. Frontiers in Physiology, 9. ISSN 1664-042X

Preview

PDF (Published manuscript) - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Amongst the major features of aging are chronic low grade inflammation and a decline in immune function. The Mediterranean diet (MedDiet) is considered to be a valuable tool to improve health status, and although beneficial effects have been reported, to date, immunological outcomes have not been extensively studied. We aimed to test the hypothesis that 1 year of a tailored intervention based on the MedDiet with vitamin D (10 μg/day) would improve innate immune responses in healthy elderly subjects (65–79 years) from the English cohort (272 subjects recruited) of the NU-AGE randomized, controlled study (clinicaltrials.gov, NCT01754012). Of the 272 subjects forming the United Kingdom cohort a subgroup of 122 subjects (61 in the intervention group and 61 in the control group) was used to evaluate ex vivo innate immune response, phenotype of circulating immune cells, and levels of pro- and anti-inflammatory markers. Odds Ratio (OR) was calculated for all the parameters analyzed. After adjustment by gender, MedDiet-females with a BMI < 31 kg/m2 had a significant upregulation of circulating CD40+CD86+ cells (OR 3.44, 95% CI 1.01–11.75, P = 0.0437). Furthermore, in all MedDiet subjects, regardless of gender, we observed a MedDiet-dependent changes, although not statistically significant of immune-critical parameters including T cell degranulation, cytokine production and co-receptor expression. Overall, our study showed that adherence to an individually tailored Mediterranean-like dietary pattern with a daily low dose of vitamin D3 supplements for 1 year modified a large variety of parameters of immune function in healthy, elderly subjects. We interpreted these data as showing that the MedDiet in later life could improve aspects of innate immunity and thus it could aid the design of strategies to counteract age-associated disturbances.

Item Type:	Article
Uncontrolled Keywords:	ageing ,dietary intervention,inflammation,nutrition,elderly
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	LivePure Connector
Date Deposited:	13 Jul 2018 14:30
Last Modified:	06 Jun 2024 15:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/67625
DOI:	10.3389/fphys.2018.00997

Downloads

Actions (login required)

View Item